https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Associations of autozygosity with a broad range of human phenotypes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45256 1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.]]> Wed 26 Oct 2022 20:06:39 AEDT ]]> Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43989 Wed 13 Mar 2024 19:11:12 AEDT ]]> Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49110 Wed 13 Mar 2024 07:53:13 AEDT ]]> A Saturated Map of Common Genetic Variants Associated with Human Height https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50431 Tue 25 Jul 2023 19:01:27 AEST ]]> A Multi-Layer Functional Genomic Analysis to Understand Noncoding Genetic Variation in Lipids https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50411 Tue 25 Jul 2023 17:30:33 AEST ]]> Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44603 Tue 18 Oct 2022 08:37:37 AEDT ]]> The power of genetic diversity in genome-wide association studies of lipids https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48599 Tue 04 Apr 2023 19:22:25 AEST ]]> Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41379 Tue 04 Apr 2023 19:08:51 AEST ]]> Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019: A systematic analysis from the Global Burden of Disease Study 2019 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53399 Thu 23 Nov 2023 13:44:14 AEDT ]]> Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46571 Fri 25 Nov 2022 11:47:21 AEDT ]]> Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42271 Fri 19 Aug 2022 14:44:24 AEST ]]> Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53055 Fri 17 Nov 2023 11:47:02 AEDT ]]> Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47296 Fri 13 Jan 2023 10:45:52 AEDT ]]> Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41791 Fri 12 Aug 2022 12:17:18 AEST ]]>